Alterations, Interactions, and Diagnostic Potential of Gut Bacteria and Viruses in Colorectal Cancer
Renyuan Gao 1 2, Yefei Zhu 2 3, Cheng Kong 2 3, Kai Xia 1 2, Hao Li 2 3, Yin Zhu 2 3, Xiaohui Zhang 2 3, Yongqiang Liu 2 3, Hui Zhong 4, Rong Yang 4, Chunqiu Chen 1 2, Nan Qin 2 3, Huanlong Qin

our study revealed the novel CRC-associated bacteria and viruses that exhibited specific differences and intensive microbial correlations, which provided a reliable diagnostic panel for CRC.

Front Cell Infect Microbiol. 2021 Jul 6;11:657867. 

SPP1 overexpression is associated with poor outcomes in ALK fusion lung cancer patients without receiving targeted therapy
Xiaolin Ji # 1, Yan Liu # 1, Fang Mei # 1, Xinyang Li 1, Mengxue Zhang 1, Buwen Yao 1, Rui Wu 1, Jiangfeng You 1, Fei Pei

"we concluded that SPP1 overexpression is associated with poor
outcomes for patients with ALK fusion lung cancer without receiving targeted therapy and PI3K/AKT/SPP1 pathway may become the promising targets in patients with aggressive lung cancer."

Sci Rep. 2021 Jul 7;11(1):14031. 

Targeted genomic profiling revealed a unique clinical phenotype in intrahepatic cholangiocarcinoma with fibroblast growth factor receptor rearrangement
Zhongzheng Zhu 1, Hui Dong 2, Jianguo Wu 1, Wei Dong 2, Xianling Guo 1, Hua Yu 2, Juemin Fang 1, Song Gao 1, Xuejun Chen 3, Huangbin Lu 3, Wenming Cong 2, Qing Xu

FGFR rearrangement is associated with unique clinical phenotypes in ICC.

Transl Oncol. 2021 Jul 9;14(10):101168. 

Next-Generation Sequencing Enhances the Diagnosis Efficiency in Thyroid Nodules
Li-Cheng Tan 1 2, Wan-Lin Liu 1 2, Xiao-Li Zhu 2 3, Peng-Cheng Yu 1 2, Xiao Shi 1 2, Pei-Zhen Han 1 2, Ling Zhang 2 3, Liang-Yu Lin 4, Arseny Semenov 5, Yu Wang 1 2, Qing-Hai Ji 1 2, Dong-Mei Ji 2 6, Yu-Long Wang 1 2, Ning Qu

"Next-generation sequencing in thyroid nodules can enhance the
preoperative diagnosis sensitivity by fine-needle aspiration alone. It can also provide genetic background for direction of medication. It is possible for clinicians to combine cytology with genetic alterations for a more precise diagnosis strategy of thyroid nodules."

Front Oncol. 2021 Jul 12;11:677892. 

NGS Analysis of Liquid Biopsy (LB) and Formalin-Fixed Paraffin-Embedded (FFPE) Melanoma Samples Using Oncomine™ Pan-Cancer Cell-Free Assay
Magdalena Olbryt 1, Marcin Rajczykowski 2, Wiesław Bal 3, Anna Fiszer-Kierzkowska 4, Alexander Jorge Cortez 5, Magdalena Mazur 4, Rafał Suwiński 2, Wiesława Widłak 1

The analysis showed both the potential and limitations of liquid biopsy genetic profiling using HD technology and the Ion Torrent platform

Genes (Basel). 2021 Jul 16;12(7):1080. 

A tailored LNA clamping design principle: Efficient, economized, specific and ultrasensitive for the detection of point mutations
Hao Yang 1, Mengqiu Yan 1, Gaolian Xu 1, Xiaohua Qian 1, Ruiying Zhao 2, Yuchen Han 2, Lin Zhang 3, Hongchen Gu 1, Hong Xu

"In this study, locked nucleic acid (LNA) was
introduced as an ampli cation suppressor of a massive number of wild-type alleles in an ampli cation refractory mutation
system (ARMS) to achieve the detection of low-abundance mutations with high speci city and sensitivity of at least 0.1%."

Biotechnol J. 2021 Jul 18;e2100233.