our study revealed the novel CRC-associated bacteria and viruses that exhibited specific differences and intensive microbial correlations, which provided a reliable diagnostic panel for CRC.

"we concluded that SPP1 overexpression is associated with poor
outcomes for patients with ALK fusion lung cancer without receiving targeted therapy and PI3K/AKT/SPP1 pathway may become the promising targets in patients with aggressive lung cancer."

FGFR rearrangement is associated with unique clinical phenotypes in ICC.

"Next-generation sequencing in thyroid nodules can enhance the
preoperative diagnosis sensitivity by fine-needle aspiration alone. It can also provide genetic background for direction of medication. It is possible for clinicians to combine cytology with genetic alterations for a more precise diagnosis strategy of thyroid nodules."

The analysis showed both the potential and limitations of liquid biopsy genetic profiling using HD technology and the Ion Torrent platform

"In this study, locked nucleic acid (LNA) was
introduced as an ampli cation suppressor of a massive number of wild-type alleles in an ampli cation refractory mutation
system (ARMS) to achieve the detection of low-abundance mutations with high speci city and sensitivity of at least 0.1%."