HER2 promotes epithelial-mesenchymal transition through regulating osteopontin in gastric cancer
Yalan Liu 1, Lingli Chen 1, Dongxian Jiang 1, Lijuan Luan 1, Jie Huang 1, Yingyong Hou 2, Chen Xu

The purpose of this study is to explore the role of OPN in epithelialmesenchymal transition (EMT) in HER2 positive GCs.

Pathol Res Pract. 2021 Nov;227:153643. 

Deep RNA Sequencing Revealed Fusion Junctional Heterogeneity May Predict Crizotinib Treatment Efficacy in ALK-Rearranged NSCLC
Zhengbo Song 1, Shifeng Lian 2, Silvia Mak 3, Maggie Zi-Ying Chow 3, Chunwei Xu 4, Wenxian Wang 1, Hoi Yee Keung 5, Chenyu Lu 6, Firaol Tamiru Kebede 7, Yanqiu Gao 8, Wah Cheuk 9, William Chi Shing Cho 10, Mengsu Yang 6, Zongli Zheng

Intratumoral EML4-ALK isoforms may predict the efficacy of targeted therapy in ALK-rearranged NSCLC. Temporal changes of intratumoral fusion isoforms may result from differential selection pressures that a drug might have on one isoform over another. Larger studies on fusion heterogeneity using RNA sequencing are warranted.

J Thorac Oncol. 2021 Oct 6;S1556-0864(21)03219-6. 

"Toripalimab plus chemotherapy as second-line treatment in previously EGFR-TKI treated patients with EGFR-mutant advanced NSCLC: a multi center phase-II trial"
Tao Jiang # 1, Pingyang Wang # 2, Jie Zhang # 1, Yanqiu Zhao 3, Jianying Zhou 4, Yun Fan 5, Yongqian Shu 6, Xiaoqing Liu 7, Helong Zhang 8, Jianxing He 9, Guanghui Gao 1, Xiaoqian Mu 3, Zhang Bao 4, Yanjun Xu 5, Renhua Guo 6, Hong Wang 7, Lin Deng 8, Ning

"Toripalimab plus chemotherapy showed a promising anti-tumor activity with acceptable safety profiles as the secondline
setting in patients with EGFR-mutant NSCLC. DSPP mutation might serve as a potential biomarker for this combination."

Signal Transduct Target Ther. 2021 Oct 15;6(1):355. 

Fine-needle Aspiration Washout Precipitation Specimens: An Acceptable Supplement to Genetic Mutation Detection of Thyroid Nodules
Yongmei Cui 1, Xiangqi Huang 1, Jinrui Guo 1, Nana Zhang 1, Jing Liang 1, Yiwang Zhang 1, Yueting Liao, Dan He

These results suggested that FNA washout precipitation specimens might be a valuable supplementary sample type for detecting the BRAF V600E mutation in patients with thyroid nodules, especially with thyroid capsule invasion.

Technol Cancer Res Treat. Jan-Dec 2021;20:15330338211057982. 

Tracking the evolution of untreated high-intermediate/high-risk diffuse large B-cell lymphoma by circulating tumour DNA
Sicong Zhang 1, Tingting Zhang 1, Hengqi Liu 1, Jing Zhao 1, Haifei Zhou 2, Xiaoxing Su 2, Xianming Liu 1, Lanfang Li 1, Lihua Qiu 1, Zhengzi Qian 1, Shiyong Zhou 1, Wenchen Gong 3, Bin Meng 3, Xiubao Ren 4, Jin He 1, Xianhuo Wang 1, Huilai Zhang

Our present results suggest that ctDNA is a promising method for the detection of mutation spectrum and serves as a biomarker for disease monitoring and predicting clinical recurrence.

Br J Haematol. 2021 Oct 19. 

PD-L1, Mismatch Repair Protein, and NTRK Immunohistochemical Expression in Cervical Small Cell Neuroendocrine Carcinoma
Longyun Chen 1, Fan Yang 1, Ting Feng 1, Shafei Wu 1, Kaimi Li 1, Junyi Pang 1, Xiaohua Shi 1, Zhiyong Liang

PD-L1 may be an effective therapeutic target for cervical SCNC. Cervical SCNC is a MMR-stable tumor and lacks NTRK gene fusion. IHC isn’t a reliable method in the detection of NTRK gene fusion in cervical SCNC.

Front Oncol. 2021 Oct 21;11:752453.